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KMID : 1151920190010030115
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Chronobiology in Medicine
2019 Volume.1 No. 3 p.115 ~ p.120
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Circadian Gene Variations Are Associated with Obsessive-Compulsive Behaviors in a Young Healthy Korean Population
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Jeong Jae-Gwon
Lee Yu-Jin
Cho Chul-Hyun
Lee Heon-Jeong
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Abstract
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Objective: The aim of this study is to evaluate the association between obsessive-compulsive behaviors and variations of circadian genes.
Methods: We evaluated whether 6 polymorphisms in 5 circadian genes CLOCK, ARNTL, NPAS2, PER2, and PER3 were associated with obsessive behaviors in a Korean population. In all, 292 healthy subjects were genotyped for 6 circadian gene variants. Obsessive-compulsive behaviors were assessed with the Korean version of Maudsley Obsessive-Compulsive Inventory (MOCI).
Results: ARNTL rs2278749 polymorphism was significantly associated with obsessive-compulsive behaviors in dominant model. PER3 rs57875989 polymorphism and obsessive-compulsive behaviors showed significant association in recessive and genotypic model. Checking and cleaning subscales of MOCI showed statistically significant difference in ARNTL genotypes.
Conclusion: The findings of this study support that circadian rhythm may influence obsessive-compulsive behaviors. Further studies are needed to explain the link between the circadian rhythm and obsessive-compulsive behavior.
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KEYWORD
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Circadian rhythms, Polymorphism, genetic, Obsessive behavior, BMAL1 protein, human, PER3 protein, human
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